Embryo-Fetal Toxicity Inform feminine sufferers of reproductive potential that acetaminophen and codeine phosphate tablets can cause fetal harm and to inform the prescriber of a known or suspected pregnancy (see PRECAUTIONS, Pregnancy).

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Life-Threatening Respiratory Depression Advise sufferers of the chance of daily life-threatening respiratory despair, which includes facts that the chance is finest when starting up acetaminophen and codeine phosphate tablets or once the dosage is improved, and that it may possibly happen even at advisable dosages.

acute or extreme bronchial asthma within an unmonitored setting or within the absence of resuscitative machines (see WARNINGS).

Do not abruptly discontinue acetaminophen and codeine phosphate tablets in patients who might be bodily dependent on opioids. Speedy discontinuation of opioid analgesics in patients that are bodily dependent on opioids has resulted in really serious withdrawal symptoms, uncontrolled suffering, and suicide.

The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are advanced.

The administration of acetaminophen and codeine phosphate tablets or other opioids might obscure the diagnosis or scientific course in clients with acute abdominal problems.

Hepatotoxicity Acetaminophen has been associated with cases of acute liver failure, sometimes leading to liver transplant and Loss of life.

Assessment has also proven that medication purchased as diazepam, and packaged to appear to be reputable medicines, contained fully unrelated substances. A single sample even contained the anaesthetic drug ketamine.

Acetaminophen and codeine phosphate tablets really should not be utilized for an extended period of time Until the discomfort click here stays severe adequate to involve an opioid analgesic and for which substitute procedure alternatives continue on being inadequate.

Even though the chance of habit in any particular person is mysterious, it may arise in sufferers properly prescribed acetaminophen and codeine phosphate tablets. Addiction can take place at advisable dosages and if the drug is misused or abused.

The codeine in acetaminophen and codeine phosphate tablets may perhaps enhance the frequency of seizures in sufferers with seizure Problems, and should improve the danger of seizures occurring in other medical options related to seizures.

Anaphylaxis: Anaphylaxis has become noted with elements contained in acetaminophen and codeine phosphate tablets.

Irrespective of guarantees because of the NHS to prioritise psychological overall health treatment method and lessen waiting around moments, use of these companies continues to be tough.